Sunday, March 31, 2013

New models predict drastically greener Arctic in coming decades

New models predict drastically greener Arctic in coming decades [ Back to EurekAlert! ] Public release date: 31-Mar-2013
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Contact: Kendra Snyder
ksnyder@amnh.org
212-496-3419
American Museum of Natural History

Boom in trees, shrubs expected to lead to net increase in climate warming

New research predicts that rising temperatures will lead to a massive "greening," or increase in plant cover, in the Arctic. In a paper published on March 31 in Nature Climate Change, scientists reveal new models projecting that wooded areas in the Arctic could increase by as much as 50 percent over the next few decades. The researchers also show that this dramatic greening will accelerate climate warming at a rate greater than previously expected.

"Such widespread redistribution of Arctic vegetation would have impacts that reverberate through the global ecosystem," said Richard Pearson, lead author on the paper and a research scientist at the American Museum of Natural History's Center for Biodiversity and Conservation.

Plant growth in Arctic ecosystems has increased over the past few decades, a trend that coincides with increases in temperatures, which are rising at about twice the global rate. The research teamwhich includes scientists from the Museum, AT&T Labs-Research, Woods Hole Research Center, Colgate University, Cornell University, and the University of Yorkused climate scenarios for the 2050s to explore how this trend is likely to continue in the future. The scientists developed models that statistically predict the types of plants that could grow under certain temperatures and precipitation. Although it comes with some uncertainty, this type of modeling is a robust way to study the Arctic because the harsh climate limits the range of plants that can grow, making this system simpler to model compared to other regions such as the tropics.

The models reveal the potential for massive redistribution of vegetation across the Arctic under future climate, with about half of all vegetation switching to a different class and a massive increase in tree cover. What might this look like? In Siberia, for instance, trees could grow hundreds of miles north of the present tree line.

"These impacts would extend far beyond the Arctic region," Pearson said. "For example, some species of birds seasonally migrate from lower latitudes and rely on finding particular polar habitats, such as open space for ground-nesting."

In addition, the researchers investigated the multiple climate change feedbacks that greening would produce. They found that a phenomenon called the albedo effect, based on the reflectivity of the Earth's surface, would have the greatest impact on the Arctic's climate. When the sun hits snow, most of the radiation is reflected back to space. But when it hits an area that's "dark," or covered in trees or shrubs, more sunlight is absorbed in the area and temperature increases. This has a positive feedback to climate warming: the more vegetation there is, the more warming will occur.

"By incorporating observed relationships between plants and albedo, we show that vegetation distribution shifts will result in an overall positive feedback to climate that is likely to cause greater warming than has previously been predicted," said co-author Scott Goetz, of the Woods Hole Research Center.

###

This work was funded by the National Science Foundation, grants IPY 0732948, IPY 0732954, and Expeditions 0832782. Other authors involved in this study include Steven Phillips (AT&T Labs-Research), Michael Loranty (Woods Hole Research Center and Colgate University), Pieter Beck (Woods Hole Research Center), Theodoros Damoulas (Cornell University), and Sarah Knight (American Museum of Natural History and University of York).



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New models predict drastically greener Arctic in coming decades [ Back to EurekAlert! ] Public release date: 31-Mar-2013
[ | E-mail | Share Share ]

Contact: Kendra Snyder
ksnyder@amnh.org
212-496-3419
American Museum of Natural History

Boom in trees, shrubs expected to lead to net increase in climate warming

New research predicts that rising temperatures will lead to a massive "greening," or increase in plant cover, in the Arctic. In a paper published on March 31 in Nature Climate Change, scientists reveal new models projecting that wooded areas in the Arctic could increase by as much as 50 percent over the next few decades. The researchers also show that this dramatic greening will accelerate climate warming at a rate greater than previously expected.

"Such widespread redistribution of Arctic vegetation would have impacts that reverberate through the global ecosystem," said Richard Pearson, lead author on the paper and a research scientist at the American Museum of Natural History's Center for Biodiversity and Conservation.

Plant growth in Arctic ecosystems has increased over the past few decades, a trend that coincides with increases in temperatures, which are rising at about twice the global rate. The research teamwhich includes scientists from the Museum, AT&T Labs-Research, Woods Hole Research Center, Colgate University, Cornell University, and the University of Yorkused climate scenarios for the 2050s to explore how this trend is likely to continue in the future. The scientists developed models that statistically predict the types of plants that could grow under certain temperatures and precipitation. Although it comes with some uncertainty, this type of modeling is a robust way to study the Arctic because the harsh climate limits the range of plants that can grow, making this system simpler to model compared to other regions such as the tropics.

The models reveal the potential for massive redistribution of vegetation across the Arctic under future climate, with about half of all vegetation switching to a different class and a massive increase in tree cover. What might this look like? In Siberia, for instance, trees could grow hundreds of miles north of the present tree line.

"These impacts would extend far beyond the Arctic region," Pearson said. "For example, some species of birds seasonally migrate from lower latitudes and rely on finding particular polar habitats, such as open space for ground-nesting."

In addition, the researchers investigated the multiple climate change feedbacks that greening would produce. They found that a phenomenon called the albedo effect, based on the reflectivity of the Earth's surface, would have the greatest impact on the Arctic's climate. When the sun hits snow, most of the radiation is reflected back to space. But when it hits an area that's "dark," or covered in trees or shrubs, more sunlight is absorbed in the area and temperature increases. This has a positive feedback to climate warming: the more vegetation there is, the more warming will occur.

"By incorporating observed relationships between plants and albedo, we show that vegetation distribution shifts will result in an overall positive feedback to climate that is likely to cause greater warming than has previously been predicted," said co-author Scott Goetz, of the Woods Hole Research Center.

###

This work was funded by the National Science Foundation, grants IPY 0732948, IPY 0732954, and Expeditions 0832782. Other authors involved in this study include Steven Phillips (AT&T Labs-Research), Michael Loranty (Woods Hole Research Center and Colgate University), Pieter Beck (Woods Hole Research Center), Theodoros Damoulas (Cornell University), and Sarah Knight (American Museum of Natural History and University of York).



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/amon-nmp032813.php

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Parkinson's disease protein gums up garbage disposal system in cells

Friday, March 29, 2013

Clumps of ?-synuclein protein in nerve cells are hallmarks of many degenerative brain diseases, most notably Parkinson's disease.

"No one has been able to determine if Lewy bodies and Lewy neurites, hallmark pathologies in Parkinson's disease can be degraded," says Virginia Lee, PhD, director of the Center for Neurodegenerative Disease Research, at the Perelman School of Medicine, University of Pennsylvania.

"With the new neuron model system of Parkinson's disease pathologies our lab has developed recently, we demonstrated that these aberrant clumps in cells resist degradation as well as impair the function of the macroautophagy system, one of the major garbage disposal systems within the cell."

Macroautophagy, literally self eating, is the degradation of unnecessary or dysfunctional cellular bits and pieces by a compartment in the cell called the lysosome.

Lee, also a professor of Pathology and Laboratory Medicine, and colleagues published their results in the early online edition of the Journal of Biological Chemistry this week.

Alpha-synuclein (?-syn ) diseases all have clumps of the protein and include Parkinson's disease (PD), and array of related disorders: PD with dementia , dementia with Lewy bodies, and multiple system atrophy. In most of these, ?-syn forms insoluble aggregates of stringy fibrils that accumulate in the cell body and extensions of neurons.

These unwanted ?-syn clumps are modified by abnormal attachments of many phosphate chemical groups as well as by the protein ubiquitin, a molecular tag for degradation. They are widely distributed in the central nervous system, where they are associated with neuron loss.

Using cell models in which intracellular ?-syn clumps accumulate after taking up synthetic ?-syn fibrils, the team showed that ?-syn inclusions cannot be degraded, even though they are located near the lysosome and the proteasome, another type of garbage disposal in the cell.

The ?-syn aggregates persist even after soluble ?-syn levels within the cell are substantially reduced, suggesting that once formed, the ?-syn inclusions are resistant to being cleared. What's more, they found that ?-syn aggregates impair the overall autophagy degradative process by delaying the maturation of autophagy machines known as autophagosomes, which may contribute to the increased cell death seen in clump-filled nerve cells. Understanding the impact of ?-syn aggregates on autophagy may help elucidate therapies for ?-syn-related neurodegeneration.

###

University of Pennsylvania School of Medicine: http://www.uphs.upenn.edu/news/

Thanks to University of Pennsylvania School of Medicine for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127519/Parkinson_s_disease_protein_gums_up_garbage_disposal_system_in_cells

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Saturday, March 30, 2013

Jeremy Renner Has a New Baby Girl!

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PST: Henry's work of art leads Bulls past Union

No question that Mike Petke (pictured) preferred not to wait five matches for his initial win as the New York Red Bulls manager. It must be like getting your first new car ? but being told it will take six weeks to ship.

Either way, New York?s slightly concerning start in 2013 can be dismissed, apparently. The Red Bulls, playing well but unable to pop the top on a sweet victory soda before Saturday, got Petke and themselves a 2-1 win against Philadelphia.

It took something special from Thierry Henry, whose wonderful game-winner was a technical work of art. Truly, Henry doesn?t just score goals, he still scores magnificent ones.

Two things should not be lost in the instinct and expertise of Henry?s awesome, 81st minute two-touch wonder:

Debuting newcomer P?guy Luyindula supplied a swell ball from just beyond the penalty area, giving Henry just enough to work with. The French midfielder, who made 130 appearances over five years at Paris Saint-Germain, already looks like a terrific find for the Red Bulls. His intelligent work off the ball matches the good work with it.

And RBNY midfielder Dax McCarty, who continues to hold his place among Major League Soccer?s most underrated brigade, scored a goal that was every bit as important as Henry?s. McCarty?s goal may not have contained the same aesthetic, but it represented the very height of useful opportunism. It was all about awareness and optimism, mixed with enough craftsmanship to finish the job.

McCarty made something from very little, a critical second-half scoring opener for his club, which was having some issues scoring goals at home before that one.

Here are Saturday?s highlights from Harrison:

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Source: http://prosoccertalk.nbcsports.com/2013/03/30/highlights-new-york-red-bulls-finally-get-a-win/related/

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Newtown rampage took just 5-minutes

Police tape seen outside the Lanza home in Newtown, Conn. (Getty Images)

NEWTOWN, Conn.?Police investigating the school massacre here seized a small arsenal of firearms, knives and swords along with medical records and computer equipment from the 20-year-old gunman's home in the days after the shootings, court documents released on Thursday reveal.

Also on Thursday, Connecticut State Attorney Stephen J. Sedensky III, who's overseeing the case, said Adam Lanza killed 26 people within five minutes of storming into Sandy Hook Elementary School before turning a gun on himself.

The documents?50 pages of affidavits and evidence logs that include a list of items seized from the car and Newtown home Lanza shared with his mother, Nancy?paint a chilling picture of a killer who had been stockpiling weapons in the weeks and months leading up to the Dec. 14 massacre.

[Related: Newtown families appear in Bloomberg anti-gun ads]

Lanza shot and killed his mother at their home before driving to the school, where he forced his way in and opened fire.

Sedensky said in a statement that Lanza killed all 26 school victims with a Bushmaster .223-caliber model XM15 rifle before taking his own life with a Glock 10 mm handgun. Lanza also had a loaded 9 mm Sig Sauer P226 handgun with him inside the school, Sedensky said, as well as three, 30-round magazines for the Bushmaster. Recovered at the scene were 154 spent bullet casings.

According to the unsealed documents, investigators found an empty box for "Battle Tested" vest accessories and hundreds of rounds of various gun ammunition inside the two-story Lanza home.

Among the other items seized (as detailed by police):

Item #71 - Receipts and emails documenting firearm/ammunition and shooting supplies.
Item #77 - Blue folder labeled "Guns" containing receipts, paperwork, and other firearm-related paperwork.
Item #81 - Paperwork titled, "Conncticut Gun Exchange, Glock 20SF 10mm FS 15 round FC," dated 12/21/11.
Item #83 - Email re: Gunbroker.com dated 10-12-11.
Item #85 - Printed photographs, miscellaneous handwritten papers, and Sandy Hook report card for Adam Lanza.
Item #86 - "Look Me in the Eye?My life with Asbergers" book, "Born on a Blue day?Inside the Mind of an Autistic Savant" book, "NRA Guide to the Basics of Pistol Shooting" book.

Exhibit # 605 - One (1) receipt for Timstar Shooting Range located in Weatherford, Ok and one (1) NRA certificate for Nancy Lanza.

Exhibit #606 - One (1) Paperback book titled "Train Your Brain To Get Happy," with pages tabbed off.

Exhibit #608 - Three (3) photographs with images of what appears to be a deceased human covered in plastic and what appears to be blood.

Exhibit #609 - Seven (7) journals and miscellaneous drawings authored by Adam Lanza.

Exhibit #612 - One (1) holiday card containing a Bank of America check #462 made out to Adam Lanza for the purchase of a C183 (Firearm), authored by Nancy Lanza.

Exhibit #630 - One (1) New York Times article on 02/18/08 of a school shooting at Northern Illinois University.

In addition to several guns inside the home, police also recovered three samurai swords and a long pole with a blade on one side and a spear on the other. Inside the car Lanza drove to the school, police recovered a 12-gauge shotgun and two magazines containing 70 rounds of ammunition, the documents show.

Adam Lanza in an undated photo (AP/File)

According to the search warrant, when officers arrived at the school, they discovered Lanza "dressed in military style clothing, wearing a bullet proof vest lying deceased on the floor in the middle classroom." He "was in possession of several handguns as well as a military style assault weapon."

When police arrived at the Lanza home, they found Nancy Lanza "lying in supine position on a bed in the 2nd floor master bedroom" with an apparent gunshot wound to the head. Investigators located a rifle "on the floor near the bed."

On Dec. 14, according to a warrant released on Thursay, FBI agents interviewed an unidentified resident who described Lanza as a "shut in" and "avid gamer who plays Call of Duty" and rarely leaves the house. The witness said Lanza had a "gun safe containing at least four guns." Lanza had attended Sandy Hook Elementary School, the person told the FBI, and "that the school was Adam Lanza's 'life.'"

Superior Court Judge John Blawie ordered parts of the documents redacted after state prosecutors requested that the identity of a key witness not be revealed for another 90 days. The judge also approved blacking out some phone, credit card and serial numbers of some of the property confiscated from the Lanza home.

Connecticut State Police briefed family members of the Newtown shooting victims on Wednesday on what was recovered inside the Lanza home and car. About 50 family members attended the briefing, according to the Connecticut Post.

Thursday's release came after state lawmakers, media and Newtown residents criticized police officials for leaking details of their investigation at a convention of police chiefs in New Orleans in March, which were then published by the New York Daily News.

[Related: Images from Newtown, Dec. 14-21, 2012]

"If state police officers can leak details of the Newtown investigation at conventions, surely that information can be shared with the Connecticut public," the Hartford Courant wrote in an editorial. "It has more of a right to know than out-of-state police chiefs do. ... This isn't information to be hoarded and shared only at the state police water cooler. The longer information is kept under wraps, the more questions there will be about why. Most important, the details will inform the debate about gun control, mental health and violence in society. There's no reason to fear an informed public."

Connecticut's General Assembly has been considering gun-control legislation in the wake of the Newtown shootings, including a ban on assault weapons and high-capacity ammunition magazines. State lawmakers said on Monday they would delay a vote on gun control until after search warrants related to the school shootings were unsealed.

The final police report on the massacre is not expected to be released until June.

Sickles reported from Dallas.

Source: http://news.yahoo.com/blogs/lookout/adam-lanza-newtown-search-warrants-released-131056789.html

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Taking the US-bound Smart Electric Drive for a spin (video)

We take the USbound Smart Electric Drive for a test drive video

The eponymous "Smart car" has been buzzing around city streets in the US for over five years now. It's actually called the Fortwo, thanks to its limited seating capacity, and while it didn't prove to be an immediate hit, sales have been steadily increasing. An electric version of the car has been available in limited numbers overseas for years now, but finally this year it's coming to the US. And this is it. We got a chance to drive a green vinyl-wrapped Smart Electric Drive around some city streets ahead of the opening of the New York International Auto Show and came away reasonably impressed by this $25,000 EV -- the cheapest on the market. Join us after the break for our impressions.

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Source: http://www.engadget.com/2013/03/29/we-take-the-us-bound-smart-electric-drive-for-a-spin-video/

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Friday, March 29, 2013

Malala Yousafzai, shot for defying Taliban, to write book

LONDON (AP) ? Malala Yousafzai, the Pakistani teenager shot in the head by the Taliban as she returned home from school, is writing a book about the traumatic event and her long-running campaign to promote children's education.

Publisher Weidenfeld and Nicolson announced it would release "I am Malala" in Britain and Commonwealth countries this fall. Little, Brown and Co. will publish the 15-year-old's memoir in the United States and much of the rest of the world.

"Malala is already an inspiration to millions around the world. Reading her story of courage and survival will open minds, enlarge hearts, and eventually allow more girls and boys to receive the education they hunger for," said Michael Pietsch, executive vice president and publisher of Little, Brown.

A Taliban gunman shot Malala on Oct. 9 in northwestern Pakistan. The militant group said it targeted her because she promoted "Western thinking" and, through a blog, had been an outspoken critic of the Taliban's opposition to educating girls.

The shooting sparked outrage in Pakistan and many other countries, and her story drew global attention to the struggle for women's rights in Malala's homeland. The teen even made the shortlist for Time magazine's "Person of the Year" in 2012.

Malala was brought to the U.K. for treatment and spent several months in a hospital undergoing skull reconstruction and cochlear implant surgeries. She was released last month and has started attending school in Britain.

Malala said in a statement Wednesday that she hoped telling her story would be "part of the campaign to give every boy and girl the right to go to school.

"I hope the book will reach people around the world, so they realize how difficult it is for some children to get access to education," she said. "I want to tell my story, but it will also be the story of 61 million children who can't get education."

FILE - In this undated file photo provided by Queen Elizabeth Hospital in Birmingham, England, Malala Yousufzai, the 15-year-old girl who was shot at close range in the head by a Taliban gunman in ... more? FILE - In this undated file photo provided by Queen Elizabeth Hospital in Birmingham, England, Malala Yousufzai, the 15-year-old girl who was shot at close range in the head by a Taliban gunman in Pakistan, reads a book as she continues her recovery at the hospital. Malala Yousafzai, the Pakistani teenager shot in the head by the Taliban, is writing a memoir. Publisher Weidenfeld and Nicolson said Thursday March 28, 2013 it will release "I am Malala" in Britain this fall. Little, Brown will publish it in the United States.A Taliban gunman shot Malala on Oct. 9, while she was on her way home from school in northwestern Pakistan. (AP Photo/Queen Elizabeth Hospital, File) less? Publishers didn't reveal the price tag for the book deal.

Source: http://news.yahoo.com/shot-pakistani-teen-malala-yousafzai-writing-book-100913748.html

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Lawmakers rush to catch up on gay marriage

FILE - In this May 11, 2010 file photo, Kay Hagan, D-N.C. speaks at a news conference on Capitol Hill in Washington. For years, American opinion on gay marriage has been shifting. Now Washington is tripping over itself trying to catch up. In less than two weeks, seven sitting senators _ all from moderate or Republican-leaning states _ announced their support, dropping one by one like dominos. Taken together, their proclamations reflected a profound change in the American political calculus: For the first time, elected officials from traditionally conservative states are starting to feel it's safer to back gay marriage than risk being the last to join the cause. (AP Photo/Harry Hamburg, File)

FILE - In this May 11, 2010 file photo, Kay Hagan, D-N.C. speaks at a news conference on Capitol Hill in Washington. For years, American opinion on gay marriage has been shifting. Now Washington is tripping over itself trying to catch up. In less than two weeks, seven sitting senators _ all from moderate or Republican-leaning states _ announced their support, dropping one by one like dominos. Taken together, their proclamations reflected a profound change in the American political calculus: For the first time, elected officials from traditionally conservative states are starting to feel it's safer to back gay marriage than risk being the last to join the cause. (AP Photo/Harry Hamburg, File)

FILE - In this Nov. 6, 2012 file photo, Sen. Claire McCaskill, D-Mo. is seen in St. Louis. For years, American opinion on gay marriage has been shifting. Now Washington is tripping over itself trying to catch up. In less than two weeks, seven sitting senators _ all from moderate or Republican-leaning states _ announced their support, dropping one by one like dominos. Taken together, their proclamations reflected a profound change in the American political calculus: For the first time, elected officials from traditionally conservative states are starting to feel it's safer to back gay marriage than risk being the last to join the cause. (AP Photo/Jeff Roberson. File)

FILE - In this March 28, 2012 file photo, Sen. Mark Begich, D-Alaska speaks on Capitol Hill in Washington. For years, American opinion on gay marriage has been shifting. Now Washington is tripping over itself trying to catch up. In less than two weeks, seven sitting senators _ all from moderate or Republican-leaning states _ announced their support, dropping one by one like dominos. Taken together, their proclamations reflected a profound change in the American political calculus: For the first time, elected officials from traditionally conservative states are starting to feel it's safer to back gay marriage than risk being the last to join the cause. (AP Photo/Jacquelyn Martin, File)

FILE - In this Sept. 17, 2012 file photo, Sen. Jon Tester, D-Mont. speaks in Billings, Mont. For years, American opinion on gay marriage has been shifting. Now Washington is tripping over itself trying to catch up. In less than two weeks, seven sitting senators _ all from moderate or Republican-leaning states _ announced their support, dropping one by one like dominos. Taken together, their proclamations reflected a profound change in the American political calculus: For the first time, elected officials from traditionally conservative states are starting to feel it's safer to back gay marriage than risk being the last to join the cause. (AP Photo/Matt Gouras, File)

FILE - In this March 21, 2013 file photo, Sen. Rob Portman, R-Ohio is seen on Capitol Hill in Washington. For years, American opinion on gay marriage has been shifting. Now Washington is tripping over itself trying to catch up. In less than two weeks, seven sitting senators _ all from moderate or Republican-leaning states _ announced their support, dropping one by one like dominos. Taken together, their proclamations reflected a profound change in the American political calculus: For the first time, elected officials from traditionally conservative states are starting to feel it's safer to back gay marriage than risk being the last to join the cause. (AP Photo/J. Scott Applewhite, File)

(AP) ? For years, American opinion on gay marriage has been shifting. Now lawmakers are in a mad dash to catch up.

In less than two weeks, seven senators ? all from moderate or Republican-leaning states ? announced their support, dropping one by one like dominos. Taken together, their proclamations reflected a profound change in the American political calculus: For the first time, elected officials from traditionally conservative states are starting to feel it's safer to back gay marriage than risk being the last to join the cause.

"As far as I can tell, political leaders are falling all over themselves to endorse your side of the case," Chief Justice John Roberts told lawyers urging the Supreme Court on Wednesday to strike down a law barring legally married gay couples from receiving federal benefits or recognition.

It was the second of two landmark gay marriage cases the justices heard this week, the high court's first major examination of gay rights in a decade. But the focus on the court cases ? replete with colorful, camera-ready protests outside the court building ? obscured the sudden emergence of a critical mass across the street in the Capitol as one by one, senators took to Facebook or quietly issued a statement to say that they, too, now support gay marriage.

For some Democrats, like Missouri Sen. Claire McCaskill and Montana Sen. Jon Tester, the reversal would have been almost unfathomable just a few months ago as they fought for re-election. The potential risks were even greater for other Democrats like North Carolina Sen. Kay Hagan and Alaska Sen. Mark Begich, already top GOP targets when they face voters next year in states that President Barack Obama lost in November. After all, it was less than a year ago that voters in Hagan's state approved a ban on gay marriage.

Those four Democrats and two others ? Mark Warner of Virginia and Jay Rockefeller of West Virginia ? were swept up in a shifting tide that began to take shape last year, when Obama, in the heat of his re-election campaign, became the first sitting president to endorse gay marriage. Former Secretary of State Hillary Rodham Clinton, a potential contender in the next presidential election, followed suit in mid-March. As support among party leaders builds, rank-and-file Democrats appear wary of being perceived as hold-outs in what both parties are increasingly describing as a civil-rights issue.

"They're reflecting what they're seeing in the polls ? except the most extreme of the Republican base," former New Jersey Gov. Christine Todd Whitman, a Republican who supports gay marriage, said in an interview. "From a purely political perspective, if you want to be a leader of the future, you look at the next generation. They are overwhelmingly in favor of this."

Reince Priebus, the chairman of the Republican Party, cautioned in a USA Today interview that the GOP should not "act like Old Testament heretics."

Among Republicans, whose party platform opposes gay marriage, the shift in position has mostly been limited to former lawmakers and prominent strategists. Still, a distinct change in tone was palpable this month when Ohio Sen. Rob Portman, a Republican whom presidential candidate Mitt Romney vetted last year as a potential running mate, declared his support, citing a personal conversion stemming from his son coming out to him as gay.

Rather than blast Portman for flouting party dogma or failing an ideological litmus test, Republican leaders shrugged, indicating that even if Republicans, as a party, aren't prepared back gay marriage, they won't hold it against those in their ranks who do.

In the Republican-controlled House, where most members come from lopsided districts heavily skewed to one party or the other, GOP leaders are not wavering publicly from their staunch opposition. In fact, when the Obama administration stopped defending the Defense of Marriage Act in court, it was House Republicans who took up the mantle. Democrats said Thursday that Republicans have spent as much as $3 million in taxpayer funds to defend the law, now before the Supreme Court.

"It's like immigration. The party realizes they are on the losing side of some of these issues," said former Rep. Jim Kolbe, an Arizona Republican. Kolbe came out as gay in 1996 while in office and will mark another milestone in May when he and his longtime partner get married in Washington.

"They want to make the shift, but you have got to do it in a politic and strategic way," Kolbe said. "It's a matter of how and when you take down one flag and run up the other."

Kolbe and Whitman joined dozens of other prominent Republicans in signing a friend-of-the-court brief urging the Supreme Court to strike down the law barring federal recognition of gay marriages. But with House Speaker John Boehner, R-Ohio, still defending the law and social conservative groups vowing payback for those who abandon it, prospects are slim that Congress will move any time soon to repeal it on its own.

"It's sort of a bandwagon effect among the cultural elite," said Peter Sprigg of the Family Research Council, which opposes gay marriage. "Some of these politicians who have changed their position, those who live in more conservative states, may pay for that shift with a defeat in their next election."

If public opinion continues to move in the direction it has been for the last 15 years, what's true for the next election may not be true just a few years down the line ? even for Republicans.

When Gallup first asked in polls about gay marriages, in 1996, just 27 percent felt they should be valid. That figure climbed to 44 percent two years ago, and reached a majority by last November, when 53 percent said gay marriages should be recognized. Among independents, a key barometer for politicians, support has jumped 23 points to 55 percent, including a six-point gain since 2010.

Even among Republicans, support has grown by 14 percentage points since 1996, although there's been no significant movement among Republicans since 2010, when 28 percent backed legal marriage.

"A lot of Republicans have come to the conclusion we can't live one life in private but advocate another life in public," said Republican strategist Alex Castellanos. "We all know families who are loving parents of the same gender who are raising great kids."

___

AP Director of Polling Jennifer Agiesta contributed to this report.

___

Reach Josh Lederman on Twitter at http://twitter.com/joshledermanAP

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-03-28-US-Gay-Marriage/id-48cd515be6ea4b479bd0ac8ee5f66052

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Attempt to end Italy crisis fails, president mulls next move

By James Mackenzie and Barry Moody

ROME (Reuters) - Center-left leader Pier Luigi Bersani has failed in his attempt to find a way out of Italy's intractable political crisis and President Giorgio Napolitano will now try to find another solution, the president's palace said on Thursday.

Bersani reported back to Napolitano on Thursday night after being given a mandate almost a week ago to see if there was a way to form a government after an inconclusive election in February which plunged Italy into deadlock.

A statement from Napolitano's office said Bersani had told him his talks with other parties "did not have a successful result."

The president would personally examine other possible solutions without delay, the statement said. Officials said Napolitano would start a new round of consultations with political parties on Friday morning.

Bersani said he had told Napolitano, 87, of the problems he had faced in the negotiations, in which he failed to reach any agreement with either of the other two main forces in parliament - Silvio Berlusconi's center-right and Beppe Grillo's populist 5-Star Movement.

A spokesman for Bersani's Democratic Party (PD) said he had not given up of forming a government but the Center-right People of Freedom (PDL) party poured scorn on the Center-left leader and said he had wasted a month in a fruitless search for support.

The Center-left fell short of the majority Bersani would need to govern after last month's election and made no headway in five days of talks with the rival parties aimed at winning sufficient support for a vote of confidence.

Napolitano has said he opposes a snap new election to end the impasse but his options are severely limited. They include naming an outsider to head a technocrat government like that of outgoing Prime Minister Mario Monti or a cross-party political coalition.

The stalemate in the euro zone's third-largest economy has been watched with growing alarm across Europe as the crisis in Cyprus increased concern about the renewal of market turmoil that would threaten the stability of the currency bloc.

On Thursday, the main indicator of market confidence, the spread between Italian 10-year bonds and their safer German counterparts widened to 350 basis points, some 30 points higher than the level seen before the February 24-25 election.

WALL

Bersani had expressed optimism up to the last minute that he could overcome the difficulties but appeared to have run into a wall, particularly in his overtures to Grillo, whose movement says it will not support a vote of confidence in a government led by either the Center-right or Center-left.

Bersani has in turn rebuffed demands by Berlusconi that he form a broad left-right coalition, saying the scandal-plagued media magnate was too discredited to deal with.

Mindful of the risk of instability, Napolitano had insisted Bersani obtain firm guarantees of support from the other parties for a vote of confidence in parliament before he would agree to give him a government-forming mandate.

Bersani had tried to win support for an agreed list of major reforms but was never able to win guaranteed backing from a sufficient number of members of parliament.

Prospects that Monti may be asked to remain in office have faded since Foreign Minister Giulio Terzi quit this week in a shock move that showed the tensions in the caretaker government.

But Bersani's struggle to reach an agreement showed how hard it will be even for a new technocrat cabinet to win support in the divided parliament, increasing the chances of a snap election.

However an election can only be called after parliament elects a successor to Napolitano, whose term ends in mid-May. Constitutional rules prevent a president from dissolving parliament during the final months of his mandate.

Even this task is politically fraught because Berlusconi wants to pick the new head of state, something Bersani rejects.

Underlining the challenges for the next government, a senior Bank of Italy official and the head of Italy's statistics agency ISTAT both said the government's latest economic forecasts may still be too optimistic, even after being sharply cut last week.

Last week the government said the economy, in its longest recession for 20 years, would contract 1.3 percent this year, compared with a previous forecast of a 0.2 percent shrinkage.

However, ISTAT head Enrico Giovannini told a parliamentary committee hearing on Thursday the result may be worse than that with no recovery until the end of the year or early 2014.

The lack of a government has increased concern that the slump will only get deeper.

"We need effective and credible economic policies to interrupt the recessionary spiral," Daniele Franco, a top central bank economist, told the committee.

(Additional reporting by Naomi O'Leary and Gavin Jones; editing by Barry Moody and Alistair Lyon)

Source: http://news.yahoo.com/italys-bersani-makes-last-ditch-appeal-government-deal-131722198.html

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Thursday, March 28, 2013

Matt Lauer Reportedly Nixes Female Producers as "Lilith Fair" Nonsense

Source: http://www.thehollywoodgossip.com/2013/03/matt-lauer-reportedly-nixes-female-producers-as-lilith-fair-nons/

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Parkinson's disease protein gums up garbage disposal system in cells

Parkinson's disease protein gums up garbage disposal system in cells [ Back to EurekAlert! ] Public release date: 28-Mar-2013
[ | E-mail | Share Share ]

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

PHILADELPHIA Clumps of ?-synuclein protein in nerve cells are hallmarks of many degenerative brain diseases, most notably Parkinson's disease.

"No one has been able to determine if Lewy bodies and Lewy neurites, hallmark pathologies in Parkinson's disease can be degraded," says Virginia Lee, PhD, director of the Center for Neurodegenerative Disease Research, at the Perelman School of Medicine, University of Pennsylvania.

"With the new neuron model system of Parkinson's disease pathologies our lab has developed recently, we demonstrated that these aberrant clumps in cells resist degradation as well as impair the function of the macroautophagy system, one of the major garbage disposal systems within the cell."

Macroautophagy, literally self eating, is the degradation of unnecessary or dysfunctional cellular bits and pieces by a compartment in the cell called the lysosome.

Lee, also a professor of Pathology and Laboratory Medicine, and colleagues published their results in the early online edition of the Journal of Biological Chemistry this week.

Alpha-synuclein (?-syn ) diseases all have clumps of the protein and include Parkinson's disease (PD), and array of related disorders: PD with dementia , dementia with Lewy bodies, and multiple system atrophy. In most of these, ?-syn forms insoluble aggregates of stringy fibrils that accumulate in the cell body and extensions of neurons.

These unwanted ?-syn clumps are modified by abnormal attachments of many phosphate chemical groups as well as by the protein ubiquitin, a molecular tag for degradation. They are widely distributed in the central nervous system, where they are associated with neuron loss.

Using cell models in which intracellular ?-syn clumps accumulate after taking up synthetic ?-syn fibrils, the team showed that ?-syn inclusions cannot be degraded, even though they are located near the lysosome and the proteasome, another type of garbage disposal in the cell.

The ?-syn aggregates persist even after soluble ?-syn levels within the cell are substantially reduced, suggesting that once formed, the ?-syn inclusions are resistant to being cleared. What's more, they found that ?-syn aggregates impair the overall autophagy degradative process by delaying the maturation of autophagy machines known as autophagosomes, which may contribute to the increased cell death seen in clump-filled nerve cells. Understanding the impact of ?-syn aggregates on autophagy may help elucidate therapies for ?-syn-related neurodegeneration.

###

Co-authors are Selcuk A. Tanik, Christine E. Schultheiss, Laura A. Volpicelli-Daley, and Kurt R. Brunden, all from Penn.

This research was funded by the National Institutes of Neurological Diseases (NS053488), the JPB Foundation, and the Jeff and Anne Keefer Fund.

Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.

The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 16 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $398 million awarded in the 2012 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Penn Medicine also includes additional patient care facilities and services throughout the Philadelphia region.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2012, Penn Medicine provided $827 million to benefit our community.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Parkinson's disease protein gums up garbage disposal system in cells [ Back to EurekAlert! ] Public release date: 28-Mar-2013
[ | E-mail | Share Share ]

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

PHILADELPHIA Clumps of ?-synuclein protein in nerve cells are hallmarks of many degenerative brain diseases, most notably Parkinson's disease.

"No one has been able to determine if Lewy bodies and Lewy neurites, hallmark pathologies in Parkinson's disease can be degraded," says Virginia Lee, PhD, director of the Center for Neurodegenerative Disease Research, at the Perelman School of Medicine, University of Pennsylvania.

"With the new neuron model system of Parkinson's disease pathologies our lab has developed recently, we demonstrated that these aberrant clumps in cells resist degradation as well as impair the function of the macroautophagy system, one of the major garbage disposal systems within the cell."

Macroautophagy, literally self eating, is the degradation of unnecessary or dysfunctional cellular bits and pieces by a compartment in the cell called the lysosome.

Lee, also a professor of Pathology and Laboratory Medicine, and colleagues published their results in the early online edition of the Journal of Biological Chemistry this week.

Alpha-synuclein (?-syn ) diseases all have clumps of the protein and include Parkinson's disease (PD), and array of related disorders: PD with dementia , dementia with Lewy bodies, and multiple system atrophy. In most of these, ?-syn forms insoluble aggregates of stringy fibrils that accumulate in the cell body and extensions of neurons.

These unwanted ?-syn clumps are modified by abnormal attachments of many phosphate chemical groups as well as by the protein ubiquitin, a molecular tag for degradation. They are widely distributed in the central nervous system, where they are associated with neuron loss.

Using cell models in which intracellular ?-syn clumps accumulate after taking up synthetic ?-syn fibrils, the team showed that ?-syn inclusions cannot be degraded, even though they are located near the lysosome and the proteasome, another type of garbage disposal in the cell.

The ?-syn aggregates persist even after soluble ?-syn levels within the cell are substantially reduced, suggesting that once formed, the ?-syn inclusions are resistant to being cleared. What's more, they found that ?-syn aggregates impair the overall autophagy degradative process by delaying the maturation of autophagy machines known as autophagosomes, which may contribute to the increased cell death seen in clump-filled nerve cells. Understanding the impact of ?-syn aggregates on autophagy may help elucidate therapies for ?-syn-related neurodegeneration.

###

Co-authors are Selcuk A. Tanik, Christine E. Schultheiss, Laura A. Volpicelli-Daley, and Kurt R. Brunden, all from Penn.

This research was funded by the National Institutes of Neurological Diseases (NS053488), the JPB Foundation, and the Jeff and Anne Keefer Fund.

Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.

The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 16 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $398 million awarded in the 2012 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Penn Medicine also includes additional patient care facilities and services throughout the Philadelphia region.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2012, Penn Medicine provided $827 million to benefit our community.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/uops-pdp032813.php

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The 10-Year-Old Security Sink Hole Slowing the Entire Internet, Explained

The largest known hack attack of its kind?brought the Internet to a crawl for users all over the world, but don't blame the hackers ? the outage all stems from an increasingly vulnerable, decade-old security problem with the "Internet's basic plumbing" that can be easily fixed. A fight between Dutch web hosting service Cyberbunker and a spam-fighting group called Spamhaus resulted in "retaliation" attacks of the distributed denial-of-service (or DDoS) variety?on Spamhouse's servers, all of which were possible because of what's called an "open DNS." While the hackers only meant to hurt Spamhouse, the method resulted in outages for the rest of the Internet at large ? or at least millions of non-hacker users ? because Cyberpunker went through a Domain Name Server, also known as the Internet's main hub, which takes website names and turns them into the ISPs that computers can understand. Specifically, the hack worked like this,?according to?The New York Times's John Markoff and Nicole Perlroth:

In the latest incident, attackers sent messages, masquerading as ones coming from Spamhaus, to those machines, which were then amplified drastically by the servers, causing torrents of data to be aimed back at the Spamhaus computers.

Because the unusually aggressive hack ? 300 billion bits per second were being sent by a network of computers, enough to take down government infrastructure ? was initially aimed at a DNS, which hosts a bunch of Internet sites, it clogged traffic for more than just Spamhouse.?

RELATED: 'Non-Humans' Account for 51% of All Internet Traffic

This type of scheming is possible in the first place, however, because of one long known hole: "Many large Internet service providers have not set up their networks to make sure that traffic leaving their networks is actually coming from their own users," explain Markoff and Perlroth. Certain DNS providers are "open," meaning they respond to queries from any ISP rather than just "authorized" clients, as cloud based web security service Cloudfare explains in this post?this post by Mathew Prince:

The problem is, many people running DNS resolvers leave them open and willing to respond to any IP address that queries them. This is a known problem that is at least 10 years old. What has happened recently is a number of distinct botnets appear to have enumerated the Internet's IP space in order to discover open resolvers. Once discovered, they can be used to launch significant DNS Amplification Attacks.

In a separate post he calls DNS the "scourge of the Internet." This hole has been known for "at least 10 years," note Markoff and Perlroth, but hackers have only started exploiting it for attacks recently. Unfortunately, the method is an increasingly popular one with increasingly powerful attacks, says Prince: "The size of these attacks will only continue to rise until all providers make a?concerted effort to close them."

RELATED: Anonymous Knocks Australian Spy Site Offline in Digital Protest

Perhaps more disconcerting than the fact that many major ISPs have a major, gaping flaw, is that once the attacks occur it's very difficult to stop their crippling effects. "You can't stop a DNS flood by shutting down those servers because those machines have to be open and public by default. The only way to deal with this problem is to find the people doing it and arrest them," security researcher Dan Kaminsky told the Times. The good news is there is a longer term solution: Close 'em up. "The best practice, if you're running a recursive DNS resolver is to ensure that it only responds to queries from authorized clients," adds Prince.?

RELATED: What Was the FBI Doing with 12 Million Apple IDs Anyway?

Image via Shutterstock by?gualtiero boffi

Source: http://news.yahoo.com/10-old-security-sink-hole-slowing-entire-internet-173316376.html

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eBay seller auctioning Jim Carrey autographed photo to buy gun

Glock handgunJim Carrey is facing plenty of backlash for his anti-gun song??Cold Dead Hand,??but one Second Amendment enthusiast is expressing his or her disagreement in a unique way ???by selling an?autographed Jim Carrey photo on eBay?to buy a new gun.

The eBay description reads, ?I?m selling this Jim Carrey Autographed B&W 8X10 Photo (mint condition) in hopes that I sell it for enough to buy a GUN to protect my family.?

Jim Carey autographThis is probably not the response Carrey had in mind when he released his song on Monday, attacking gun owners and singing lyrics such as ?the psychos win no matter what you do because they?ll always buy more guns than you.?

The picture seller, astrobuzz, hopes to net at least $640 to buy a ?Glock G30S .45 ACP Pistol.? If the photo goes for more than the price of the gun, the seller promises to spend the extra cash on a laser for the gun along with gun safety classes and a concealed carry permit.

It looks like the seller will be toting around a new Glock in no time, as the bidding was already up to $860 on Wednesday, with 5 days left to bid.

In case there was any doubt, the seller said the choice to sell the item was in response to Carrey?s extremely offensive, anti-Second Amendment song.

?I lost all respect for Mr. Carrey after he released his ?Cold Dead Hands? video mocking responsible gun owners and Charlton Heston,? the seller wrote in the eBay description. ?I believe in the 2nd Amendment and my rights shall not be infringed! From MY cold dead hands Mr. Carrey!?

The picture itself is a portrait of Carrey along with his John Hancock and the message ?Spank you very much!? ? to which the future Glock owner says, ?And spank u. Jim.?

Yee haw!

Source: http://redalertpolitics.com/2013/03/27/ebay-seller-auctioning-jim-carrey-autographed-photo-to-buy-gun/

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Wednesday, March 27, 2013

Huawei could be readying another powerful Samsung Galaxy S4 rival

Huawei may be putting the finishing touches to a Samsung Galaxy S4 challenger as details leak on a new high-powered handset.

According to Chinese website mobile163, Huawei is planning another quad-core handset which is set to launch in April.

The report suggests the currently nameless device will pack a 1.8GHz quad-core processor, 4.9-inch full HD display, 2GB of RAM, 13MP camera and a 2,600mAh.

Again, again, I love repetition

It also claims Huawei will pack all this tech into a body which is just 6.3mm thick, which makes us fear the handset in question could be pretty bezel-heavy to compensate.

If true, it's a slightly puzzling decision from the Chinese firm as it's already announced two quad-core handsets this year, with the 5-inch Ascend D2 breaking cover at CES 2013 and the 4.7-inch Ascend P2 arriving at MWC 2013.

The advantage of Huawei releasing another flagship smartphone is that it will be thrown into the minds of consumers again, and if it's priced cheaper than the Galaxy S4 it may well tempt some away from Samsung's offering.

Via UnwiredView

Source: http://www.techradar.com/news/phone-and-communications/mobile-phones/huawei-could-be-readying-another-powerful-samsung-galaxy-s4-rival-1140340?src=rss&attr=all

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Tuesday, March 26, 2013

Antibiotic may provide benefit for treatment of respiratory disorder

Mar. 26, 2013 ? Among patients with the lung disorder non-cystic fibrosis bronchiectasis, treatment with the antibiotic azithromycin or erythromycin resulted in improvement in symptoms but also increased the risk of antibiotic resistance, according to two studies appearing in the March 27 issue of JAMA.

Bronchiectasis is characterized by abnormal widening of the bronchi (air tubes that branch deep into the lungs) and can cause recurrent lung infections, a disabling cough, shortness of breath, and coughing up blood. "If progressive, this process may lead to respiratory failure and the need for lung transplantation or to death," according to background information in one study. Macrolide (a class of antibiotics) antibiotics have antibacterial and anti-inflammatory properties that conceivably would provide effective treatment of bronchiectasis. These antibiotics have been shown beneficial in treating cystic fibrosis (CF), and findings from small studies suggest a benefit in non-CF bronchiectasis.

Josje Altenburg, M.D., of the Medical Centre Alkmaar, the Netherlands, and colleagues conducted a multicenter trial to investigate whether 1 year of low-dose macrolide treatment added to standard therapy is effective in reducing exacerbation frequency in patients with non-CF bronchiectasis. The randomized, placebo-controlled trial was conducted between April 2008 and September 2010 in 14 hospitals in the Netherlands among 83 outpatients with non-CF bronchiectasis and 3 or more lower respiratory tract infections in the preceding year. Patients received azithromycin (250 mg daily) or placebo for 12 months.

Forty-three participants (52 percent) received azithromycin and 40 (48 percent) received placebo and were included in the modified intention-to-treat analysis. A total of 117 exacerbations treated with antibiotics were reported during 1 year of treatment, 78 of which occurred in the placebo group. "During the treatment period, the median [midpoint] number of exacerbations in the azithromycin group was 0, compared with 2 in the placebo group. Of the 40 participants receiving placebo, 32 (80 percent) had at least 1 exacerbation during the study period. In the 43 participants receiving azithromycin, 20 (46.5 percent) had at least 1 exacerbation in the same period, yielding an absolute risk reduction of 33.5 percent. The number of patients needed to treat with azithromycin to maintain clinical stability was 3.0," the authors write.

"Gastrointestinal adverse effects occurred in 40 percent of patients in the azithromycin group and in 5 percent in the placebo group but without need for discontinuation of study treatment. A macrolide resistance rate of 88 percent was noted in azithromycin-treated individuals, compared with 26 percent in the placebo group."

"We conclude that macrolide maintenance therapy was effective in reducing exacerbations in patients with non-CF bronchiectasis. In this trial, azithromycin treatment resulted in improved lung function and better quality of life but involved an increase in gastrointestinal adverse effects and high rates of macrolide resistance," the authors write.

In another study, David J. Serisier, M.B.B.S., D.M., F.R.A.C.P., of Mater Adult Hospital, South Brisbane, Australia, and colleagues tested the hypothesis that low-dose erythromycin would reduce pulmonary exacerbations in patients with non-CF bronchiectasis with a history of frequent exacerbations.

The study consisted of a 12-month randomized controlled trial of erythromycin in currently nonsmoking, adult patients with non-CF bronchiectasis with a history of 2 or more infective exacerbations in the preceding year. The study was undertaken between October 2008 and December 2011 in a university teaching hospital. Patients received twice-daily erythromycin ethylsuccinate (400 mg) or matching placebo. The primary measured outcome was the annualized average rate of protocol-defined pulmonary exacerbations (PDPEs) per patient. Secondary outcomes included macrolide resistance and lung function.

Six-hundred seventy-nine patients were screened, 117 were randomized (58 placebo, 59 erythromycin), and 107 (91.5 percent) completed the study. The researchers found that erythromycin significantly reduced PDPEs (76 for the erythromycin group vs. 114 for the placebo group; average 1.29 vs. 1.97 respectively, per patient per year). The number of patients treated with erythromycin who had zero PDPEs was 20 (vs. 16 for placebo), and 10 patients had more than 2 PDPEs (vs. 18, respectively).

Erythromycin also reduced PDPEs in the prespecified subgroup with baseline Pseudomonas aeruginosa airway infection. In addition, there were significantly fewer total respiratory events (total PDPEs plus non-PDPEs) in the erythromycin group (111 vs. 176 for placebo; average, 1.88 vs. 3.03 per patient per year).

"Erythromycin reduced 24-hour sputum production and attenuated [lessened] lung function decline compared with placebo. Erythromycin increased the proportion of macrolide-resistant oropharyngeal streptococci," the authors write.

"In conclusion, long-term low-dose erythromycin significantly reduced exacerbations, protected against lung function decline, reduced sputum production, and significantly increased macrolide resistance in oropharyngeal streptococci. The bacterial resistance caused by macrolide therapy mandates a cautious application of this therapy in clinical practice. Further studies are needed to evaluate the possibility that P aerugmosa-infected individuals with frequent exacerbations may represent an appropriate subgroup for limitation of this therapy."

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Story Source:

The above story is reprinted from materials provided by The JAMA Network Journals.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal References:

  1. Josje Altenburg et al. Effect of Azithromycin Maintenance Treatment on Infectious Exacerbations Among Patients With Non?Cystic Fibrosis BronchiectasisThe BAT Randomized Controlled TrialAzithromycin for Adults With Non-CF Bronchiectasis. JAMA, 2013; 309 (12): 1251 DOI: 10.1001/jama.2013.1937
  2. David J. Serisier et al. Effect of Long-term, Low-Dose Erythromycin on Pulmonary Exacerbations Among Patients With Non?Cystic Fibrosis BronchiectasisThe BLESS Randomized Controlled TrialLow-Dose Erythromycin for Pulmonary Exacerbations. JAMA, 2013; 309 (12): 1260 DOI: 10.1001/jama.2013.2290

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/805Uy541XCM/130326162332.htm

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Family Handyman Magazine Subscription for $4.99

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2013

by Jaime. This post may contain affiliate links. Read my Disclosure Policy.

Get a one year subscription to Family Handyman?Magazine for?$4.99. To get this deal, just use coupon code SAVINGWITHSHELLIE at checkout. You can buy up to 4 years at $4.99 per year. This deal is only valid today (3/25). This is valid on new or renewal subscriptions.

About Family Handyman?Magazine:

Family Handyman Magazine is for people who take an active interest in home improvement, yard and garden care, maintenance and repair, and remodeling. Family Handyman also features information on woodworking, auto maintenance, energy efficiency, and decorating.

The editors of Family Handyman Magazine have also put out a book called 101 Saturday Morning Projects. Inside you?ll find easy-to-follow, sensible projects like building a summer lounge chair, installing a dimmer switch and adding extra storage space. All the projects will keep your home and yard in tip-top shape and all can be done in less than 4 hours.

If you already subscribe and want more great ideas, check out 101 Saturday Morning Projects. It has great reviews and might make a nice gift for the project man in your life.

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US Labor Department announces new online resources to help ...

WASHINGTON?- The U.S. Department of Labor today announced the launch of the Business Center, a suite of online resources for employers looking to recruit, train and retain a skilled work force through the department?s CareerOneStop Web site.

?

The site includes tips about how to recruit qualified candidates through local American Job Centers and provides employment projections. Additionally, the site offers access to local training and educational institutions, a catalog of occupational certifications and a tool to help employers translate the military training and skills of returning service members into specific civilian occupations. The CareerOneStop Business Center is available online at?http://www.careeronestop.org/business.

?

?These resources will help educate employers about our nation?s work force development system and put the resources they need to find and hire qualified workers right at their fingertips,? said Jane Oates, assistant secretary of labor for employment and training.

?

The new Business Center page builds on existing resources available through CareerOneStop, which also has information to help job seekers find education and training providers, conduct a job search and access local labor market information.

?

Employment and Training Administration staff will have a webinar on March 27 at 2 p.m. EDT to highlight the Business Center?s tools. A webinar is a seminar conducted over the Internet. For more information and to participate in the webinar, visit?https://www.workforce3one.org/view/5001307743087754858/info.

?

Short URL: http://www.hawaiireporter.com/?p=312837

Author: Guest Contributor

To be a guest contributor, submit your story to Malia@hawaiireporter.com. Check out past stories by guest contributors!

Guest Contributor has written 2611 articles for us.

Source: http://www.hawaiireporter.com/us-labor-department-announces-new-online-resources-to-help-businesses-recruit-train-and-retain-a-skilled-work-force/123

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